A previous hemorrhagic stroke protects against a subsequent stroke via microglia alternative polarization

Shin-Shin Lee; Li Pang; Yin Cheng; Jia Xin Liu; Anson Cho Kiu Ng; Gilberto Ka Kit Leung

doi:10.1038/s42003-022-03621-4

Communications Biology (Jul 2022)

A previous hemorrhagic stroke protects against a subsequent stroke via microglia alternative polarization

Shin-Shin Lee,
Li Pang,
Yin Cheng,
Jia Xin Liu,
Anson Cho Kiu Ng,
Gilberto Ka Kit Leung

Affiliations

Shin-Shin Lee: Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong
Li Pang: Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong
Yin Cheng: Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong
Jia Xin Liu: Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong
Anson Cho Kiu Ng: Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong
Gilberto Ka Kit Leung: Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong

DOI: https://doi.org/10.1038/s42003-022-03621-4
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 12

Abstract

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Microglia shift in polarization from an M1 to a M2 phenotype following a past “mini” stroke, resulting in better neurological function recovery, faster attenuation of lesion volume, and better survival.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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