VIOLATION OF FOLATE METABOLISM AS A POSSIBLE CAUSE OF PREGNANCY LOSS. A CLINICAL CASE

Abstract

The article describes a case of successfully reversing folate metabolism disorders in a patient with genetic mutations in the folate cycle genes MTHFR and MTRR, and multiple developmental defects in fetuses (spina bifida) during their history. Folate deficiency increases the risk of pregnancy complications, miscarriage and fetal malformations. The use of standard folic acid dosages proved ineffective, and the fetus developed spina bifida. The formation of developmental defects in the fetus was prevented by increasing the recommended dosage of folic acid.

Keywords

• фолиевая кислота
• метафолин
• гипергомоцистеинемия
• дефекты нервной трубки плода
• прегравидарная подготовка