Human induced pluripotent stem cells generated from a 45-years-old male donor of type 2 diabetes mellitus with APOE-epsilon3/epsilon3 alleles

Shuxing Cao; Ruiyun Guo; Jinyu Zhang; Xin Liu; Zijing Zhou; Yongzhou Song; Jun Ma

Stem Cell Research (Aug 2022)

Human induced pluripotent stem cells generated from a 45-years-old male donor of type 2 diabetes mellitus with APOE-epsilon3/epsilon3 alleles

Shuxing Cao,
Ruiyun Guo,
Jinyu Zhang,
Xin Liu,
Zijing Zhou,
Yongzhou Song,
Jun Ma

Affiliations

Shuxing Cao: The Second Hospital of Hebei Medical University, Hebei Province 050017, China
Ruiyun Guo: Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China
Jinyu Zhang: Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China
Xin Liu: Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China
Zijing Zhou: Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China
Yongzhou Song: The Second Hospital of Hebei Medical University, Hebei Province 050017, China; Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China; Corresponding authors at: The Second Hospital of Hebei Medical University, Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China (Y. Song). Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Human Anatomy Department, Hebei Medical University, Hebei Province 050017, China (J. Ma).
Jun Ma: Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China; Human Anatomy Department, Hebei Medical University, Hebei Province 050017, China; Corresponding authors at: The Second Hospital of Hebei Medical University, Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China (Y. Song). Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Human Anatomy Department, Hebei Medical University, Hebei Province 050017, China (J. Ma).

Journal volume & issue: Vol. 63
p. 102840

Abstract

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Apolipoprotein E (APOE) gene encodes three protein isoforms (APOEε-22/ε-33/ε-44), which governs the transportation and metabolism of lipoproteins differently. While abnormalities in lipid and lipoprotein metabolism have been identified as risk factors for type 2 diabetes mellitus (T2DM). APOE gene polymorphisms might be correlated with increased risk of T2DM. Therefore, we presented an iPSC line harboring an APOE-ε3/ε3 alleles, a male donor suffering from T2DM combined with Hypertension. The derived iPSCs showed pluripotency, the capacity to differentiate into three germ layers, and normal karyotypes. Collectively, the present study provides a useful resource to reveal the associated mechanism of APOE isoform and T2DM.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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