The Potential Neuroprotective Effect of <i>Cyperus esculentus</i> L. Extract in Scopolamine-Induced Cognitive Impairment in Rats: Extensive Biological and Metabolomics Approaches

Marwa M. Saeed; Álvaro Fernández-Ochoa; Fatema R. Saber; Rabab H. Sayed; María de la Luz Cádiz-Gurrea; Amira K. Elmotayam; Francisco Javier Leyva-Jiménez; Antonio Segura-Carretero; Rania I. Nadeem

doi:10.3390/molecules27207118

Molecules (Oct 2022)

The Potential Neuroprotective Effect of <i>Cyperus esculentus</i> L. Extract in Scopolamine-Induced Cognitive Impairment in Rats: Extensive Biological and Metabolomics Approaches

Marwa M. Saeed,
Álvaro Fernández-Ochoa,
Fatema R. Saber,
Rabab H. Sayed,
María de la Luz Cádiz-Gurrea,
Amira K. Elmotayam,
Francisco Javier Leyva-Jiménez,
Antonio Segura-Carretero,
Rania I. Nadeem

Affiliations

Marwa M. Saeed: Lecturer of Pharmacology and Toxicology, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt
Álvaro Fernández-Ochoa: Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Avda Fuentenueva s/n, 18071 Granada, Spain
Fatema R. Saber: Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
Rabab H. Sayed: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
María de la Luz Cádiz-Gurrea: Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Avda Fuentenueva s/n, 18071 Granada, Spain
Amira K. Elmotayam: Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
Francisco Javier Leyva-Jiménez: Department of Analytical Chemistry and Food Science and Technology, University of Castilla-La Mancha, Ronda de Calatrava, 7, 13071 Ciudad Real, Spain
Antonio Segura-Carretero: Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Avda Fuentenueva s/n, 18071 Granada, Spain
Rania I. Nadeem: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt

DOI: https://doi.org/10.3390/molecules27207118
Journal volume & issue: Vol. 27, no. 20
p. 7118

Abstract

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The aim of the present study is to investigate the phytochemical composition of tiger nut (TN) (Cyperus esculentus L.) and its neuroprotective potential in scopolamine (Scop)-induced cognitive impairment in rats. The UHPLC-ESI-QTOF-MS analysis enabled the putative annotation of 88 metabolites, such as saccharides, amino acids, organic acids, fatty acids, phenolic compounds and flavonoids. Treatment with TN extract restored Scop-induced learning and memory impairments. In parallel, TN extract succeeded in lowering amyloid beta, β-secretase protein expression and acetylcholine esterase (AChE) activity in the hippocampus of rats. TN extract decreased malondialdehyde levels, restored antioxidant levels and reduced proinflammatory cytokines as well as the Bax/Bcl2 ratio. Histopathological analysis demonstrated marked neuroprotection in TN-treated groups. In conclusion, the present study reveals that TN extract attenuates Scop-induced memory impairments by diminishing amyloid beta aggregates, as well as its anti-inflammatory, antioxidant, anti-apoptotic and anti-AChE activities.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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