Incoherent Optical Fluctuation Flowmetry: A New Method for the Assessment of Foot Perfusion in Patients with Diabetes-Related Lower-Extremity Complications
Polina Glazkova,
Alexey Glazkov,
Dmitry Kulikov,
Sergei Zagarov,
Yulia Kovaleva,
Alina Babenko,
Yulia Kononova,
Elena Kitaeva,
Timur Britvin,
Natalia Mazur,
Roman Larkov,
Dmitry Rogatkin
Affiliations
Polina Glazkova
Moscow Regional Research and Clinical Institute (“MONIKI”), 129110 Moscow, Russia
Alexey Glazkov
Moscow Regional Research and Clinical Institute (“MONIKI”), 129110 Moscow, Russia
Dmitry Kulikov
Medical Faculty, Moscow Region State University, 141014 Mytishchi, Russia
Sergei Zagarov
Moscow Regional Research and Clinical Institute (“MONIKI”), 129110 Moscow, Russia
Yulia Kovaleva
Moscow Regional Research and Clinical Institute (“MONIKI”), 129110 Moscow, Russia
Alina Babenko
Almazov National Medical Research Centre, 197341 St. Petersburg, Russia
Yulia Kononova
Almazov National Medical Research Centre, 197341 St. Petersburg, Russia
Elena Kitaeva
Almazov National Medical Research Centre, 197341 St. Petersburg, Russia
Timur Britvin
Moscow Regional Research and Clinical Institute (“MONIKI”), 129110 Moscow, Russia
Natalia Mazur
Moscow Regional Research and Clinical Institute (“MONIKI”), 129110 Moscow, Russia
Roman Larkov
Moscow Regional Research and Clinical Institute (“MONIKI”), 129110 Moscow, Russia
Dmitry Rogatkin
Moscow Regional Research and Clinical Institute (“MONIKI”), 129110 Moscow, Russia
(1) Background: To date, there are no studies evaluating the ability of the incoherent optical fluctuation flowmetry (IOFF) method to assess foot tissue perfusion. The aim of this study was to evaluate the correlation between perfusion values measured by IOFF and TcPO2 in patients with diabetes-related lower-extremity complications. (2) Methods: This was an observational, cross-sectional, two-center study. Diabetic patients with peripheral artery disease and/or diabetic foot ulcers were studied (n = 27, examinations were carried out on 54 legs). Perfusion in the foot tissues was assessed using TcPO2 (reference standard for this study) and the IOFF method. (3) Results: High correlation coefficients of all perfusion parameters measured by IOFF with TcPO2 (Rs 0.7 to 0.76) were shown. The study demonstrated that the IOFF method allows, with a sensitivity of 85.7% and a specificity of 90.0%, the identification of patients with a critical decrease in TcPO2 2 and the moderately high sensitivity and specificity in detecting patients with severe ischemia of foot tissues shows the promise of the method for assessing a tissue perfusion in patients with diabetes-related lower-extremity complications.
