Nature Communications (Aug 2020)

Identification of modified peptides using localization-aware open search

  • Fengchao Yu,
  • Guo Ci Teo,
  • Andy T. Kong,
  • Sarah E. Haynes,
  • Dmitry M. Avtonomov,
  • Daniel J. Geiszler,
  • Alexey I. Nesvizhskii

DOI
https://doi.org/10.1038/s41467-020-17921-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 9

Abstract

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Mass spectrometry-based proteomics is the method of choice for the global mapping of post-translational modifications, but matching and scoring peaks with unknown masses remains challenging. Here, the authors present a refined open search strategy to score all peaks with higher sensitivity and accuracy.