Nature Communications (Jul 2018)
HIV-1 targets L-selectin for adhesion and induces its shedding for viral release
- Joseph Kononchik,
- Joanna Ireland,
- Zhongcheng Zou,
- Jason Segura,
- Genevieve Holzapfel,
- Ashley Chastain,
- Ruipeng Wang,
- Matthew Spencer,
- Biao He,
- Nicole Stutzman,
- Daiji Kano,
- James Arthos,
- Elizabeth Fischer,
- Tae-Wook Chun,
- Susan Moir,
- Peter Sun
Affiliations
- Joseph Kononchik
- Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Joanna Ireland
- Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Zhongcheng Zou
- Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Jason Segura
- Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Genevieve Holzapfel
- Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Ashley Chastain
- Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Ruipeng Wang
- Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Matthew Spencer
- Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Biao He
- Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Nicole Stutzman
- Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Daiji Kano
- Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- James Arthos
- Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Elizabeth Fischer
- Research Technology Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Tae-Wook Chun
- Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Susan Moir
- Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Peter Sun
- Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-018-05197-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
HIV binding is mediated via CD4 and chemokine co-receptors, but this does not explain the preferential infection of central memory CD4+ T cells. Here the authors show HIV targets L-selectin, induces shedding from the infected cell, and inhibition of L-selectin reduces HIV infection and release.
