MECHANISMS FOR THE FORMATION MYOCARDIAL FIBROSIS IN NORM AND IN CERTAIN CARDIOVASCULAR DISEASES, HOW TO DIAGNOSE IT

Abstract

The review summarizes current knowledge regarding the origins and role of myocardial fibrosis formation, including the effects of humoral and cellular components. The concepts of extracellular matrix and volume, their clinical significance for the progression of cardiovascular diseases, the background for the formation of new approaches for the treatment of cardiac pathology are considered, taking into account the results of determination of extracellular volume with the help of MRI.

Keywords

• cardiac fibrosis
• collagen
• extracellular matrix
• extracellular volume
• cardiovascular magnetic resonance imaging