Nature Communications (May 2020)

A cysteine selenosulfide redox switch for protein chemical synthesis

  • Vincent Diemer,
  • Nathalie Ollivier,
  • Bérénice Leclercq,
  • Hervé Drobecq,
  • Jérôme Vicogne,
  • Vangelis Agouridas,
  • Oleg Melnyk

DOI
https://doi.org/10.1038/s41467-020-16359-6
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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Control of cysteine reactivity is of paramount importance for the synthesis of proteins using native chemical ligation. Here, the authors report a readily cleavable N-selenoethyl group attached to cysteine and apply it to the modular assembly of linear and cyclic polypeptides.