Identification reproducible microbiota biomarkers for the diagnosis of cirrhosis and hepatocellular carcinoma

Huarong Zhang; Junling Wu; Yijuan Liu; Yongbin Zeng; Zhiyu Jiang; Haidan Yan; Jie Lin; Weixin Zhou; Qishui Ou; Lu Ao

doi:10.1186/s13568-023-01539-6

AMB Express (Mar 2023)

Identification reproducible microbiota biomarkers for the diagnosis of cirrhosis and hepatocellular carcinoma

Huarong Zhang,
Junling Wu,
Yijuan Liu,
Yongbin Zeng,
Zhiyu Jiang,
Haidan Yan,
Jie Lin,
Weixin Zhou,
Qishui Ou,
Lu Ao

Affiliations

Huarong Zhang: Key Laboratory of Ministry of Education for Gastrointestinal Cancer, the School of Basic Medical Sciences, Fujian Medical University
Junling Wu: Department of Bioinformatics, Fujian Key Laboratory of Medical Bioinformatics, School of Medical Technology and Engineering, Fujian Medical University
Yijuan Liu: Department of Bioinformatics, Fujian Key Laboratory of Medical Bioinformatics, School of Medical Technology and Engineering, Fujian Medical University
Yongbin Zeng: Department of Laboratory Medicine, Gene Diagnosis Research Center, The First Affiliated Hospital of Fujian Medical University
Zhiyu Jiang: Department of Bioinformatics, Fujian Key Laboratory of Medical Bioinformatics, School of Medical Technology and Engineering, Fujian Medical University
Haidan Yan: Key Laboratory of Ministry of Education for Gastrointestinal Cancer, the School of Basic Medical Sciences, Fujian Medical University
Jie Lin: Department of Bioinformatics, Fujian Key Laboratory of Medical Bioinformatics, School of Medical Technology and Engineering, Fujian Medical University
Weixin Zhou: Department of Bioinformatics, Fujian Key Laboratory of Medical Bioinformatics, School of Medical Technology and Engineering, Fujian Medical University
Qishui Ou: Department of Laboratory Medicine, Gene Diagnosis Research Center, The First Affiliated Hospital of Fujian Medical University
Lu Ao: Key Laboratory of Ministry of Education for Gastrointestinal Cancer, the School of Basic Medical Sciences, Fujian Medical University

DOI: https://doi.org/10.1186/s13568-023-01539-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Key points Gut microbial biomarkers across Chinese population can be used as a non-invasive tool for the diagnosis of LC and HCC We constructed two RFmodels based on reproducible genera to distinguish LC or HCC from HC The efficacy of two models was greatly improved when clinical factors were added

Published in AMB Express

ISSN: 2191-0855 (Online)
Publisher: SpringerOpen
Country of publisher: United Kingdom
LCC subjects: Technology: Chemical technology: Biotechnology; Science: Microbiology
Website: http://www.amb-express.com/

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Abstract

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