Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation

Huiyi Liang; Bo Peng; Cong Dong; Lixin Liu; Jiaji Mao; Song Wei; Xinlu Wang; Hanshi Xu; Jun Shen; Hai-Quan Mao; Xiaohu Gao; Kam W. Leong; Yongming Chen

doi:10.1038/s41467-018-06603-5

Nature Communications (Oct 2018)

Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation

Huiyi Liang,
Bo Peng,
Cong Dong,
Lixin Liu,
Jiaji Mao,
Song Wei,
Xinlu Wang,
Hanshi Xu,
Jun Shen,
Hai-Quan Mao,
Xiaohu Gao,
Kam W. Leong,
Yongming Chen

Affiliations

Huiyi Liang: Center for Functional Biomaterials, School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Sun Yat-sen University
Bo Peng: Center for Functional Biomaterials, School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Sun Yat-sen University
Cong Dong: Center for Functional Biomaterials, School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Sun Yat-sen University
Lixin Liu: Center for Functional Biomaterials, School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Sun Yat-sen University
Jiaji Mao: Department of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Song Wei: General Hospital of Guangzhou Military Command of PLA
Xinlu Wang: General Hospital of Guangzhou Military Command of PLA
Hanshi Xu: Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University
Jun Shen: Department of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Hai-Quan Mao: Center for Functional Biomaterials, School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Sun Yat-sen University
Xiaohu Gao: Center for Functional Biomaterials, School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Sun Yat-sen University
Kam W. Leong: Center for Functional Biomaterials, School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Sun Yat-sen University
Yongming Chen: Center for Functional Biomaterials, School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Sun Yat-sen University

DOI: https://doi.org/10.1038/s41467-018-06603-5
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

Read online

Cell-free DNA (cfDNA) released from damaged or dead cells can activate DNA sensors that exacerbate the pathogenesis of rheumatoid arthritis (RA). Here the authors use ~40 nm cationic nanoparticles to scavenge cfDNA, and demonstrate the potential for nanomedicine to relieve debilitating RA symptoms.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal