Skeletal muscle dissemination in a dog with T‐cell lymphoma

Abstract

Abstract A 5‐year‐old spayed female American Staffordshire was referred for weakness, reluctance to move and distension of the abdomen. Three weeks before, the dog underwent surgery for excision of a nodular mass suspected to be a non‐epitheliotropic cutaneous T‐cell lymphoma (NE‐CTCL). Computed tomography revealed heterogeneous enhancing mesenteric masses and nodular lesions of soft tissue density, and infiltration of the abdominal muscular wall. Moreover, a pattern of diffuse muscle nodules in the skeletal muscles was visible, with lesions showing homogenous, heterogeneous or ring enhancement. Necrosis was histologically observed and these lesions were infiltrated by CD3‐positive and CD20‐, CD79a‐ and Iba1‐negative neoplastic lymphocytes. On the basis of the immunopathological features metastatic NE‐CTCL was suspected. Skeletal muscle metastasis has been rarely reported in small animals and this case report further confirms that this possibility should be considered in dogs with lymphoma.

Keywords

• canine lymphoma
• computed tomography
• muscle metastasis
• neoplastic invasion
• non‐epitheliotropic cutaneous T‐cell lymphoma
• oncologic staging