Real-time imaging of cellular forces using optical interference

Andrew T. Meek; Nils M. Kronenberg; Andrew Morton; Philipp Liehm; Jan Murawski; Eleni Dalaka; Jonathan H. Booth; Simon J. Powis; Malte C. Gather

doi:10.1038/s41467-021-23734-4

Nature Communications (Jun 2021)

Real-time imaging of cellular forces using optical interference

Andrew T. Meek,
Nils M. Kronenberg,
Andrew Morton,
Philipp Liehm,
Jan Murawski,
Eleni Dalaka,
Jonathan H. Booth,
Simon J. Powis,
Malte C. Gather

Affiliations

Andrew T. Meek: SUPA, School of Physics and Astronomy, University of St Andrews, North Haugh
Nils M. Kronenberg: SUPA, School of Physics and Astronomy, University of St Andrews, North Haugh
Andrew Morton: SUPA, School of Physics and Astronomy, University of St Andrews, North Haugh
Philipp Liehm: SUPA, School of Physics and Astronomy, University of St Andrews, North Haugh
Jan Murawski: SUPA, School of Physics and Astronomy, University of St Andrews, North Haugh
Eleni Dalaka: SUPA, School of Physics and Astronomy, University of St Andrews, North Haugh
Jonathan H. Booth: SUPA, School of Physics and Astronomy, University of St Andrews, North Haugh
Simon J. Powis: School of Medicine, University of St Andrews, North Haugh
Malte C. Gather: SUPA, School of Physics and Astronomy, University of St Andrews, North Haugh

DOI: https://doi.org/10.1038/s41467-021-23734-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

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Studying dynamic processes in mechanobiology has been challenging due to lack of appropriate tools. Here, the authors present an interference-based method, illuminated via two rapidly alternating wavelengths, which enables real-time mapping of nanoscale forces with sub-second mechanical fluctuations.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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