C-reactive Protein and D-dimer levels correlates with covid-19 severity and mortality: a retrospective study

Abstract

Background: Certain laboratory markers can be used as predictors of COVID-19 prognosis. Elevated levels of cardiac D-dimer, C-reactive protein (CRP), lactate dehydrogenase, and Troponin-I are thought to be associated with poor outcomes, although this must be proven again. The aim of this research is to determine the correlation between CRP and D-dimer levels and severity and mortality in patients. Materials and Methods: This research is a retrospective cohort study conducted between January 2021 and December 2021. A total of 51 patient medical records that met the inclusion and exclusion criteria were analyzed. The binomial logistic regression test was used to analyze the correlation between CRP levels and D-dimer levels, respectively, on the severity and mortality of COVID-19. Results: In this study, the mean CRP level was 12.6 ± 3.2 mg/dL in nonsevere COVID-19 cases and 21.5 ± 1.9 mg/dL in severe cases (P = 0.008). In nonsevere COVID-19, the mean D-dimer level was 334.7 ± 68.5 ng/mL compared to the severe cases of 2156.8 ± 431 ng/mL. The Mann–Whitney test showed a significant difference between nonsevere and severe COVID-19 (P < 0.001). There was a significant difference between CRP (P = 0.016) and D-dimer (P < 0.001) levels between survivors and nonsurvivors. Multivariate regression analysis found that increased D-dimer levels were associated with an increased degree of severity of COVID-19 (P = 0.001) and increased CRP levels were associated with increased mortality from COVID-19. Conclusion: An increase in D-dimer levels is significant as a predictor of COVID-19 severity and increase in CRP levels is significant as a predictor of COVID-19 mortality.

Keywords

• covid-19 mortality
• covid-19 severity
• crp levels
• d-dimer levels