Nature Communications (Nov 2022)

Metabolic and proteomic signatures of type 2 diabetes subtypes in an Arab population

  • Shaza B. Zaghlool,
  • Anna Halama,
  • Nisha Stephan,
  • Valborg Gudmundsdottir,
  • Vilmundur Gudnason,
  • Lori L. Jennings,
  • Manonanthini Thangam,
  • Emma Ahlqvist,
  • Rayaz A. Malik,
  • Omar M. E. Albagha,
  • Abdul Badi Abou‑Samra,
  • Karsten Suhre

DOI
https://doi.org/10.1038/s41467-022-34754-z
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 17

Abstract

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Four T2D subtypes were previously identified: severe insulin deficient, severe insulin resistant, mild obesity-related, and mild age-related diabetes. Here, the authors show that these subtypes can be translated to an Arabic population and identify distinct subtype-specific metabolic and proteomic signatures.