Journal of Diabetes (Nov 2022)
在中国男性和女性中肥胖介导了相反的教育对糖尿病关联:REACTION研究的结果
- Yuanyue Zhu,
- Chunyan Hu,
- Lin Lin,
- Shuangyuan Wang,
- Hong Lin,
- Yanan Huo,
- Qin Wan,
- Yingfen Qin,
- Ruying Hu,
- Lixin Shi,
- Qing Su,
- Xuefeng Yu,
- Li Yan,
- Guijun Qin,
- Xulei Tang,
- Gang Chen,
- Min Xu,
- Yu Xu,
- Tiange Wang,
- Zhiyun Zhao,
- Zhengnan Gao,
- Guixia Wang,
- Feixia Shen,
- Zuojie Luo,
- Li Chen,
- Qiang Li,
- Zhen Ye,
- Yinfei Zhang,
- Chao Liu,
- Youmin Wang,
- Shengli Wu,
- Tao Yang,
- Huacong Deng,
- Lulu Chen,
- Tianshu Zeng,
- Jiajun Zhao,
- Yiming Mu,
- Weiqing Wang,
- Guang Ning,
- Yufang Bi,
- Yuhong Chen,
- Jieli Lu
Affiliations
- Yuanyue Zhu
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Chunyan Hu
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Lin Lin
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Shuangyuan Wang
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Hong Lin
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Yanan Huo
- Jiangxi Provincial People's Hospital Affiliated to Nanchang University Nanchang China
- Qin Wan
- The Affiliated Hospital of Luzhou Medical College Luzhou China
- Yingfen Qin
- The First Affiliated Hospital of Guangxi Medical University Nanning China
- Ruying Hu
- Zhejiang Provincial Center for Disease Control and Prevention Hangzhou China
- Lixin Shi
- Affiliated Hospital of Guiyang Medical University Guiyang China
- Qing Su
- Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai China
- Xuefeng Yu
- Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China
- Li Yan
- Sun Yat‐sen Memorial Hospital, Sun Yat‐sen University Guangzhou China
- Guijun Qin
- The First Affiliated Hospital of Zhengzhou University Zhengzhou China
- Xulei Tang
- The First Hospital of Lanzhou University Lanzhou China
- Gang Chen
- Fujian Provincial Hospital, Fujian Medical University Fuzhou China
- Min Xu
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Yu Xu
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Tiange Wang
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Zhiyun Zhao
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Zhengnan Gao
- Dalian Municipal Central Hospital Affiliated of Dalian Medical University Dalian China
- Guixia Wang
- The First Hospital of Jilin University Changchun China
- Feixia Shen
- The First Affiliated Hospital of Wenzhou Medical University Wenzhou China
- Zuojie Luo
- The First Affiliated Hospital of Guangxi Medical University Nanning China
- Li Chen
- Qilu Hospital of Shandong University Jinan China
- Qiang Li
- The Second Affiliated Hospital of Harbin Medical University Harbin China
- Zhen Ye
- Zhejiang Provincial Center for Disease Control and Prevention Hangzhou China
- Yinfei Zhang
- Central Hospital of Shanghai Jiading District Shanghai China
- Chao Liu
- Jiangsu Province Hospital on Integration of Chinese and Western Medicine Nanjing China
- Youmin Wang
- The First Affiliated Hospital of Anhui Medical University Hefei China
- Shengli Wu
- Karamay Municipal People's Hospital Xinjiang China
- Tao Yang
- The First Affiliated Hospital of Nanjing Medical University Nanjing China
- Huacong Deng
- The First Affiliated Hospital of Chongqing Medical University Chongqing China
- Lulu Chen
- Union Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China
- Tianshu Zeng
- Union Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China
- Jiajun Zhao
- Shandong Provincial Hospital affiliated to Shandong University Jinan China
- Yiming Mu
- Chinese People's Liberation Army General Hospital Beijing China
- Weiqing Wang
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Guang Ning
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Yufang Bi
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Yuhong Chen
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Jieli Lu
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- DOI
- https://doi.org/10.1111/1753-0407.13325
- Journal volume & issue
-
Vol. 14,
no. 11
pp. 739 – 748
Abstract
Abstract Background Evidence regarding the impact of education on diabetes risk is scarce in developing countries. We aimed to explore the association between education and diabetes within a large population in China and to identify the possible mediators between them. Methods Information on educational level and lifestyle factors was collected through questionnaires. Diabetes was diagnosed from self‐report and biochemical measurements. A structural equation model was constructed to quantify the mediation effect of each mediator. Results Compared with their least educated counterparts, men with college education had a higher risk of diabetes (odds ratio [OR] 1.19; 95% confidence interval [CI], 1.12–1.27), while college‐educated women were less likely to have diabetes (OR 0.77; 95% CI, 0.73–0.82). Obesity was the strongest mediator in both genders (proportion of mediation: 11.6% in men and 23.9% in women), and its association with education was positive in men (β[SE] 0.0387 [0.0037]) and negative in women (β[SE] −0.0824 [0.0030]). Taken together, all behavioral factors explained 12.4% of the excess risk of diabetes in men and 33.3% in women. Conclusions In a general Chinese population, the association between education level and diabetes was positive in men but negative in women. Obesity was the major mediator underlying the education disparities of diabetes risk, with a stronger mediation effect among women.
Keywords
