Nature Communications (Apr 2016)
Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition
- Jian Fang,
- Jingdong Cheng,
- Jiaolong Wang,
- Qiao Zhang,
- Mengjie Liu,
- Rui Gong,
- Ping Wang,
- Xiaodan Zhang,
- Yangyang Feng,
- Wenxian Lan,
- Zhou Gong,
- Chun Tang,
- Jiemin Wong,
- Huirong Yang,
- Chunyang Cao,
- Yanhui Xu
Affiliations
- Jian Fang
- Department of Systems Biology for Medicine, Key Laboratory of Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Shanghai Medical College of Fudan University
- Jingdong Cheng
- Department of Systems Biology for Medicine, Key Laboratory of Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Shanghai Medical College of Fudan University
- Jiaolong Wang
- State Key Laboratory of Bio-organic and Natural Product Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- Qiao Zhang
- Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University
- Mengjie Liu
- Department of Systems Biology for Medicine, Key Laboratory of Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Shanghai Medical College of Fudan University
- Rui Gong
- Department of Systems Biology for Medicine, Key Laboratory of Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Shanghai Medical College of Fudan University
- Ping Wang
- Department of Systems Biology for Medicine, Key Laboratory of Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Shanghai Medical College of Fudan University
- Xiaodan Zhang
- Department of Systems Biology for Medicine, Key Laboratory of Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Shanghai Medical College of Fudan University
- Yangyang Feng
- Department of Systems Biology for Medicine, Key Laboratory of Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Shanghai Medical College of Fudan University
- Wenxian Lan
- State Key Laboratory of Bio-organic and Natural Product Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- Zhou Gong
- State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences
- Chun Tang
- State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences
- Jiemin Wong
- Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University
- Huirong Yang
- Department of Systems Biology for Medicine, Key Laboratory of Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Shanghai Medical College of Fudan University
- Chunyang Cao
- State Key Laboratory of Bio-organic and Natural Product Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- Yanhui Xu
- Department of Systems Biology for Medicine, Key Laboratory of Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Shanghai Medical College of Fudan University
- DOI
- https://doi.org/10.1038/ncomms11197
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 12
Abstract
UHRF1 is involved in the maintenance of DNA methylation, but the regulatory mechanism of this epigenetic regulator is unclear. Here, the authors show that it has a closed conformation and are able to make conclusions about the mechanism of recognition of epigenetic marks.
