Theta dominates cross-frequency coupling in hippocampal-medial entorhinal circuit during awake-behavior in rats
Yuchen Zhou,
Alex Sheremet,
Jack P. Kennedy,
Yu Qin,
Nicholas M. DiCola,
Sarah D. Lovett,
Sara N. Burke,
Andrew P. Maurer
Affiliations
Yuchen Zhou
Engineering School of Sustainable Infrastructure & Environment (ESSIE), University of Florida, 365 Weil Hall, Gainesville, FL 32611, USA; Department of Psychiatry, Yale School of Medicine, 300 George Street, New Haven, CT 06511, USA
Alex Sheremet
Engineering School of Sustainable Infrastructure & Environment (ESSIE), University of Florida, 365 Weil Hall, Gainesville, FL 32611, USA; Department of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, P.O. Box 100244, 1149 Newell Drive, RML 1-100G, Gainesville, FL 32610, USA
Jack P. Kennedy
Department of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, P.O. Box 100244, 1149 Newell Drive, RML 1-100G, Gainesville, FL 32610, USA
Yu Qin
Engineering School of Sustainable Infrastructure & Environment (ESSIE), University of Florida, 365 Weil Hall, Gainesville, FL 32611, USA
Nicholas M. DiCola
Department of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, P.O. Box 100244, 1149 Newell Drive, RML 1-100G, Gainesville, FL 32610, USA
Sarah D. Lovett
Department of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, P.O. Box 100244, 1149 Newell Drive, RML 1-100G, Gainesville, FL 32610, USA
Sara N. Burke
Department of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, P.O. Box 100244, 1149 Newell Drive, RML 1-100G, Gainesville, FL 32610, USA
Andrew P. Maurer
Engineering School of Sustainable Infrastructure & Environment (ESSIE), University of Florida, 365 Weil Hall, Gainesville, FL 32611, USA; Department of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, P.O. Box 100244, 1149 Newell Drive, RML 1-100G, Gainesville, FL 32610, USA; Correspondence
Summary: Hippocampal theta and gamma rhythms are hypothesized to play a role in the physiology of higher cognition. Prior research has reported that an offset in theta cycles between the entorhinal cortex, CA3, and CA1 regions promotes independence of population activity across the hippocampus. In line with this idea, it has recently been observed that CA1 pyramidal cells can establish and maintain coordinated place cell activity intrinsically, with minimal reliance on afferent input. Counter to these observations is the contemporary hypothesis that CA1 neuron activity is driven by a gamma oscillation arising from the medial entorhinal cortex (MEC) that relays information by providing precisely timed synchrony between MEC and CA1. Reinvestigating this in rats during appetitive track running, we found that theta is the dominant frequency of cross-frequency coupling between the MEC and hippocampus, with hippocampal gamma largely independent of entorhinal gamma.
