DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity

• Maria Jure-Kunkel,
• Homer C Adams III,
• Kate Sasser,
• Mark Fereshteh,
• Alexander Muik,
• Isil Altintas,
• Friederike Gieseke,
• Aras Toker,
• Özlem Türeci,
• Tahamtan Ahmadi,
• Ugur Sahin,
• Dennis Verzijl,
• Kristina B Schoedel,
• Jordan M Blum,
• Bianca Sänger,
• Saskia M Burm,
• Eliana Stanganello,
• Vanessa M Spires,
• Fulvia Vascotto,
• Juliane Quinkhardt,
• Mustafa Diken,
• David P E Satijn,
• Sebastian Kreiter,
• Esther C W Breij

Affiliations

Maria Jure-Kunkel

2Genmab A/S, Utrecht, Netherlands

Homer C Adams III

Janssen Pharmaceutical Companies of Johnson and Johnson, Philadelphia, Pennsylvania, USA

Kate Sasser

Genmab, Princeton, NJ, USA

Mark Fereshteh

2Genmab A/S, Utrecht, Netherlands

Alexander Muik

1BioNTech SE, Mainz, Germany

Isil Altintas

2Genmab A/S, Utrecht, Netherlands

Friederike Gieseke

1BioNTech SE, Mainz, Germany

Aras Toker

1BioNTech SE, Mainz, Germany

Özlem Türeci

1BioNTech SE, Mainz, Germany

Tahamtan Ahmadi

2Genmab A/S, Utrecht, Netherlands

Ugur Sahin

1BioNTech SE, Mainz, Germany

Dennis Verzijl

Genmab, Utrecht, Netherlands

Kristina B Schoedel

BioNTech SE, Mainz, Germany

Jordan M Blum

Genmab US Inc, Plainsboro, New Jersey, USA

Bianca Sänger

BioNTech SE, Mainz, Germany

Saskia M Burm

Translational Research and Precision Medicine, Genmab BV, Utrecht, The Netherlands

Eliana Stanganello

TRON—Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Mainz, Germany

Vanessa M Spires

Genmab US Inc, Plainsboro, New Jersey, USA

Fulvia Vascotto

TRON—Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Mainz, Germany

Juliane Quinkhardt

BioNTech SE, Mainz, Germany

Mustafa Diken

BioNTech SE, Mainz, Germany

David P E Satijn

Genmab BV, Utrecht, The Netherlands

Sebastian Kreiter

BioNTech SE, Mainz, Germany

Esther C W Breij

Translational Research and Precision Medicine, Genmab BV, Utrecht, The Netherlands