PLoS ONE (Jan 2015)

Rapid Antiretroviral Therapy Initiation for Women in an HIV-1 Prevention Clinical Trial Experiencing Primary HIV-1 Infection during Pregnancy or Breastfeeding.

  • Susan Morrison,
  • Grace John-Stewart,
  • John J Egessa,
  • Sezi Mubezi,
  • Sylvia Kusemererwa,
  • Dennis K Bii,
  • Nulu Bulya,
  • Francis Mugume,
  • James D Campbell,
  • Jonathan Wangisi,
  • Elizabeth A Bukusi,
  • Connie Celum,
  • Jared M Baeten,
  • Partners PrEP Study Team

DOI
https://doi.org/10.1371/journal.pone.0140773
Journal volume & issue
Vol. 10, no. 10
p. e0140773

Abstract

Read online

During an HIV-1 prevention clinical trial in East Africa, we observed 16 cases of primary HIV-1 infection in women coincident with pregnancy or breastfeeding. Nine of eleven pregnant women initiated rapid combination antiretroviral therapy (ART), despite having CD4 counts exceeding national criteria for ART initiation; breastfeeding women initiated ART or replacement feeding. Rapid ART initiation during primary HIV-1 infection during pregnancy and breastfeeding is feasible in this setting.