Ecologic analysis of antimicrobial use in South Carolina hospitals during 2020–2022

Pamela Bailey; Shujie Chen; Majdi N. Al-Hasan; Bankole Olatosi; Xiaoming Li; Jiajia Zhang

doi:10.1017/ash.2023.496

Antimicrobial Stewardship & Healthcare Epidemiology (Jan 2023)

Ecologic analysis of antimicrobial use in South Carolina hospitals during 2020–2022

Pamela Bailey,
Shujie Chen,
Majdi N. Al-Hasan,
Bankole Olatosi,
Xiaoming Li,
Jiajia Zhang

Affiliations

Pamela Bailey: ORCiD; Department of Internal Medicine, Division of Infectious Diseases, Prisma Health—Midlands, Columbia, SC, USA University of South Carolina School of Medicine, Columbia, SC, USA
Shujie Chen: Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA Big Data Health Science Center, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA
Majdi N. Al-Hasan: ORCiD; Department of Internal Medicine, Division of Infectious Diseases, Prisma Health—Midlands, Columbia, SC, USA University of South Carolina School of Medicine, Columbia, SC, USA
Bankole Olatosi: ORCiD; Big Data Health Science Center, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA Department of Health Services Policy and Management, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA
Xiaoming Li: ORCiD; Big Data Health Science Center, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA Department of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina; Columbia, SC, USA
Jiajia Zhang: Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA Big Data Health Science Center, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA

DOI: https://doi.org/10.1017/ash.2023.496
Journal volume & issue: Vol. 3

Abstract

Read online

Abstract Background: Factors influencing excessive antimicrobial utilization in hospitalized patients remain poorly understood, particularly with the COVID-19 pandemic. Methods: In this retrospective cohort, we compared administrative data regarding antimicrobial prescriptions in hospitalized patients in South Carolina from March 2020 through September 2022. The study examined variables associated with antimicrobial use across demographics, COVID status, and length of stay, among other variables. Results: Significant relationships were seen with antimicrobial use in COVID-19 positive patients (OR 2.00, 95% Confidence Interval (CI): 1.9–2.1), young adults (OR 1.08, 95% CI: 0.99–1.12, COVID-19 positive Blacks and Hispanics (OR 1.06, 95% CI: 1.01–1.11, OR 1.05, 95% CI: 0.89–1.23), and COVID-19 positive patients with ≥2 comorbid conditions (OR 1.55, 95% CI: 1.43–1.68). Discussion: Further analysis in more than one healthcare system should explore these ecologic relationships further to understand if these are common trends to inform ongoing stewardship interventions.

Published in Antimicrobial Stewardship & Healthcare Epidemiology

ISSN: 2732-494X (Online)
Publisher: Cambridge University Press
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Medicine: Public aspects of medicine
Website: https://www.cambridge.org/core/journals/antimicrobial-stewardship-and-healthcare-epidemiology

About the journal