Frontiers in Cardiovascular Medicine (Sep 2022)

Anti-inflammatory role of SGLT2 inhibitors as part of their anti-atherosclerotic activity: Data from basic science and clinical trials

  • Lucia Scisciola,
  • Vittoria Cataldo,
  • Fatemeh Taktaz,
  • Rosaria Anna Fontanella,
  • Ada Pesapane,
  • Puja Ghosh,
  • Martina Franzese,
  • Armando Puocci,
  • Antonella De Angelis,
  • Liberata Sportiello,
  • Raffaele Marfella,
  • Raffaele Marfella,
  • Michelangela Barbieri

DOI
https://doi.org/10.3389/fcvm.2022.1008922
Journal volume & issue
Vol. 9

Abstract

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Atherosclerosis is a progressive inflammatory disease leading to mortality and morbidity in the civilized world. Atherosclerosis manifests as an accumulation of plaques in the intimal layer of the arterial wall that, by its subsequent erosion or rupture, triggers cardiovascular diseases. Diabetes mellitus is a well-known risk factor for atherosclerosis. Indeed, Type 2 diabetes mellitus patients have an increased risk of atherosclerosis and its associated-cardiovascular complications than non-diabetic patients. Sodium-glucose co-transport 2 inhibitors (SGLT2i), a novel anti-diabetic drugs, have a surprising advantage in cardiovascular effects, such as reducing cardiovascular death in a patient with or without diabetes. Numerous studies have shown that atherosclerosis is due to a significant inflammatory burden and that SGLT2i may play a role in inflammation. In fact, several experiment results have demonstrated that SGLT2i, with suppression of inflammatory mechanism, slows the progression of atherosclerosis. Therefore, SGLT2i may have a double benefit in terms of glycemic control and control of the atherosclerotic process at a myocardial and vascular level. This review elaborates on the anti-inflammatory effects of sodium-glucose co-transporter 2 inhibitors on atherosclerosis.

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