The systemic inflammatory response index is associated with chronic kidney disease in patients with hypertension: data from the national health and nutrition examination study 1999–2018
Yani Wang,
Lihua Liao,
Qian Guo,
Ying Liao,
Xueqin Lin,
Huilan Li,
Lin Deng,
Yufei Deng,
Danni Guo,
Kaihong Chen,
Yong Fang
Affiliations
Yani Wang
Department of Cardiovascular Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China
Lihua Liao
Department of Cardiovascular Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China
Qian Guo
Department of Cardiovascular Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China
Ying Liao
Department of Cardiovascular Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China
Xueqin Lin
Department of Cardiovascular Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China
Huilan Li
Department of Cardiovascular Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China
Lin Deng
Department of Cardiovascular Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China
Yufei Deng
Department of Cardiovascular Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China
Danni Guo
Department of Cardiovascular Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China
Kaihong Chen
Department of Cardiovascular Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China
Yong Fang
Department of Cardiovascular Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China
Background Studies have shown that in hypertensive patients, chronic kidney disease (CKD) is associated with a poor prognosis. Inflammation is a highly important factor in the progression of CKD. Detecting systemic inflammation and intervening promptly in patients with hypertension may help reduce the risk of CKD. The systemic inflammatory response index (SIRI) is a tool used to measure the systemic inflammatory response, but its relationship with CKD in patients with hypertension remains uncertain.Methods We utilized data from the National Health and Nutrition Examination Survey (NHANES), which was conducted between 1999 and 2018. The analysis included a total of 20,243 participants, categorized into three groups based on SIRI tertiles. Logistic regression analysis and restricted cubic spline analysis were used to examine the relationship between the SIRI and CKD.Results In patients with hypertension, there was a notable relationship between the SIRI and the odds of developing CKD. After full adjustment, there was a 31% greater likelihood of developing CKD associated with each incremental increase of 1 unit in the SIRI (OR: 1.31, 95% CI: 1.24–1.39, p < 0.001). The groups with greater SIRI values exhibited greater odds of developing CKD than did the T1 group (T2: OR: 1.20, 95% CI: 1.04–1.38, p = 0.015; T3: OR: 1.69, 95% CI: 1.47–1.94, p < 0.001).Conclusion A high SIRI is associated with an increased risk of CKD in hypertensive patients. The greater the SIRI is, the greater the risk of CKD in hypertensive patients.
