Advances in Mechanism of Coexistence and Pharmaceutical Treatment of Chronic Heart Failure and Depression

Abstract

The coprevalence of chronic heart failure (CHF) and depression is 10%-79%, the pathogenesis of these two diseases is related to the activation of immune inflammatory system, insulin resistance and intestinal flora imbalance, and relevant regulation is bidirectional and complex. There is a lack of efficient drugs for both CHF and depression recommended by available diagnosis and treatment guidelines and present clinical practice. But it has recently been reported that some drugs (sacubitril/valsartan, new antidepressants, shensongyangxin and qiliqiangxin capsules, regulators of the intestinal flora) may be partially effective for CHF with depression.We reviewed the mechanism of coexistence and pharmaceutical treatment of CHF and depression, providing new ideas and evidence for clinical diagnosis and treatment of CHF and depression.

Keywords

• |heart failure|depressive disorder|comorbidity|multiple chronic conditions|drug therapy|review