Prevalence of endothelial dysfunction and dyslipidemia in patients with chronic rheumatic heart disease

Abstract

The article presents the results of the study of endothelial function (EF) and lipid spectrum in 114 patients with chronic rheumatic heart disease (CRHD) during 5 years. The average age of the patients was 58.68 ±0.47 years; 18 men (15.8%) and 96 women (84.2%). Angioscan-01 apparatus was used to study EF. The occlusion index amplitude was reduced in all patients with CRHD. The minimum values of EF in the system of small resistive arteries were in patients with I functional class (FQ of chronic heart failure: 1.39 ± 0.07, and the maximum with II FO 1.73 ± 0.16. In the system of large conductive arteries, on the contrary, more pronounced changes are noted in II FC (-10,36 ± 2,07) and III FC (-8,94 ± 2,23), and the smallest in I FC (1,46 ± 6,69). The augmentation index showed high rigidity of the vascular wall and tended to decrease from the group with FC I (15,65 ± 2,05%) to the group with FC III (13,06 ± 2,35), but the difference was statistically insignificant. The age of the vascular wall varied significantly from 62.88 ± 3.46 years (I FC) to 70.71 ± 2.74 years (III FC). The values of total cholesterol (5.14 ± 0.12 and 5.48 ± 0.20 mm/l, after 5 years) and low-density lipoproteins (2.75 ± 0.09 and 2.72 ± 0.12 mm/l, after 5 years) did not change. Thus, patients with СRHD have EF disorders both in large conductive arteries (phase shift -6.64 ± 1.95 and -4.42 ± 2.29 ms, after 5 years) and in the microcirculation system (occlusion index 1.40 ± 0.09 and 1.46 ± 0.08, after 5 years) without significant dynamics during 5 years of observation.

Keywords

• chronic rheumatic heart disease
• mitral stenosis
• endothelial dysfunction
• occlusion test