Nature Communications (Mar 2017)
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
- Russell L. McLaughlin,
- Dick Schijven,
- Wouter van Rheenen,
- Kristel R. van Eijk,
- Margaret O’Brien,
- René S. Kahn,
- Roel A. Ophoff,
- An Goris,
- Daniel G. Bradley,
- Ammar Al-Chalabi,
- Leonard H. van den Berg,
- Jurjen J. Luykx,
- Orla Hardiman,
- Jan H. Veldink,
- Project MinE GWAS Consortium,
- Schizophrenia Working Group of the Psychiatric Genomics Consortium
Affiliations
- Russell L. McLaughlin
- Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin
- Dick Schijven
- Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht
- Wouter van Rheenen
- Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht
- Kristel R. van Eijk
- Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht
- Margaret O’Brien
- Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin
- René S. Kahn
- Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht
- Roel A. Ophoff
- Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht
- An Goris
- Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven—University of Leuven
- Daniel G. Bradley
- Smurfit Institute of Genetics, Trinity College Dublin
- Ammar Al-Chalabi
- Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King’s College London
- Leonard H. van den Berg
- Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht
- Jurjen J. Luykx
- Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht
- Orla Hardiman
- Smurfit Institute of Genetics, Trinity College Dublin
- Jan H. Veldink
- Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht
- Project MinE GWAS Consortium
- Schizophrenia Working Group of the Psychiatric Genomics Consortium
- DOI
- https://doi.org/10.1038/ncomms14774
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Relatives of patients with amyotrophic lateral sclerosis have an unexpectedly high incidence of schizophrenia. Here, the authors show a genetic link between the two conditions, suggesting shared neurobiological mechanisms.
