Metal-Free Synthesis of Carbamoylated Chroman-4-Ones via Cascade Radical Annulation of 2-(Allyloxy)arylaldehydes with Oxamic Acids
Long-Yong Xie,
Sha Peng,
Li-Hua Yang,
Xiao-Wen Liu
Affiliations
Long-Yong Xie
Key Laboratory of Comprehensive Utilization of Advantage Plants Resources of Southern Hunan, College of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou 425100, China
Sha Peng
Key Laboratory of Comprehensive Utilization of Advantage Plants Resources of Southern Hunan, College of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou 425100, China
Li-Hua Yang
Key Laboratory of Comprehensive Utilization of Advantage Plants Resources of Southern Hunan, College of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou 425100, China
Xiao-Wen Liu
Key Laboratory of Comprehensive Utilization of Advantage Plants Resources of Southern Hunan, College of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou 425100, China
An efficient and straightforward approach for the synthesis of carbamoylated chroman-4-ones has been well-developed. The reaction is triggered through the generation of carbamoyl radicals from oxamic acids under metal-free conditions, which subsequently undergoes decarboxylative radical cascade cyclization on 2-(allyloxy)arylaldehydes to afford various amide-containing chroman-4-one scaffolds with high functional group tolerance and a broad substrate scope.
