Communications Biology (Sep 2022)

PU.1-c-Jun interaction is crucial for PU.1 function in myeloid development

  • Xinhui Zhao,
  • Boris Bartholdy,
  • Yukiya Yamamoto,
  • Erica K. Evans,
  • Meritxell Alberich-Jordà,
  • Philipp B. Staber,
  • Touati Benoukraf,
  • Pu Zhang,
  • Junyan Zhang,
  • Bon Q. Trinh,
  • John D. Crispino,
  • Trang Hoang,
  • Mahmoud A. Bassal,
  • Daniel G. Tenen

DOI
https://doi.org/10.1038/s42003-022-03888-7
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 15

Abstract

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The transcription factor PU.1 recruits c-Jun as a co-activator to promoters without AP-1 binding sites, and mice with point mutations in PU.1 that disrupts the interaction between PU1 and c-Jun have defects in PU.1 dependent blood lineages, including macrophages and B cells.