Nature Communications (Mar 2021)

A computational workflow for the expansion of heterologous biosynthetic pathways to natural product derivatives

  • Jasmin Hafner,
  • James Payne,
  • Homa MohammadiPeyhani,
  • Vassily Hatzimanikatis,
  • Christina Smolke

DOI
https://doi.org/10.1038/s41467-021-22022-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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The top down cheminformatics method is usually used for the reconstitution of heterologous pathway to produce plant natural products. Here, the authors report a bottom up computational workflow for the identification of potential products and the enzymes required to make them in a noscapine pathway in yeast.