Acta Biomedica Scientifica (May 2013)
EVALUATION OF HEMOGRAM INDICATORS AND CYTOKINE STATUS IN HEALTHY ADOLESCENTS LIVING IN THE INDUSTRIAL CITY OF IRKUTSK REGION
Abstract
Development of technical progress causes increasing anthropogenic pressure that adversely affect human health. The most important environmental factor is the quality of atmospheric air. Children and adolescents are the most sensitive group to the effects of environmental factors. The aim of the study was to examine the performance of hemogram and cytokine status of healthy adolescents living in the industrial cities of Irkutsk region with different levels of technogenic pressure. The healthy adolescents of 14-17 years were examined. Group 1 consisted of teenagers, who are living in the city with high level of air pollution (Angarsk). The control group (group 11) consisted of adolescents from the city with medium level of pollution (Sayansk). Hemogram parameters, the content ofinterleukins-2 and -10, alpha- and gamma-interferon in serum were studied. Statistical processing of the results was performed by nonparametric tests using the software package Statistica 6.0. Differences were considered statistically significant at p < 0,05. An analysis of the performance of hemogram revealed that the number of teenagers from Angarsk stab neutrophils and basophils was significantly lower than in the peer group of Sayansk. The level of hemoglobin and erythrocyte sedimentation rate of teenagers from the group 1 were lower than in the comparison group. Average levels of interleukins-2 and -10 in serum in a group of schoolchildren from Angarsk exceeded those of the surveyed Sayansk. Despite the absence of between-group differences in the content of alpha- and gamma-interferon, the proportion of people with high levels of gamma-interferon in the group 1 was higher and amounted to 36,36 %. 1n this case average group values of all the studied parameters were within the reference levels. 1n general changes were determined for indicators of hemogram and cytokine status in healthy adolescents living in the town with high level of air pollution: specifically higher amount of granulocytic white blood cells and lower levels ofinterleukins-2 and -10. These changes may reflect the response of healthy adolescents to air pollution by chemical pollutants and indicate sensitivity to antigenic exposure and preparednessfor response to it.
