Journal of Clinical Medicine (Jun 2021)
Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study
- María Chaparro,
- Ana Garre,
- Andrea Núñez Ortiz,
- María Teresa Diz-Lois Palomares,
- Cristina Rodríguez,
- Sabino Riestra,
- Milagros Vela,
- José Manuel Benítez,
- Estela Fernández Salgado,
- Eugenia Sánchez Rodríguez,
- Vicent Hernández,
- Rocío Ferreiro-Iglesias,
- Ángel Ponferrada Díaz,
- Jesús Barrio,
- José María Huguet,
- Beatriz Sicilia,
- María Dolores Martín-Arranz,
- Xavier Calvet,
- Daniel Ginard,
- Inmaculada Alonso-Abreu,
- Luis Fernández-Salazar,
- Pilar Varela Trastoy,
- Montserrat Rivero,
- Isabel Vera-Mendoza,
- Pablo Vega,
- Pablo Navarro,
- Mónica Sierra,
- José Luis Cabriada,
- Mariam Aguas,
- Raquel Vicente,
- Mercè Navarro-Llavat,
- Ana Echarri,
- Fernando Gomollón,
- Elena Guerra del Río,
- Concepción Piñero,
- María José Casanova,
- Katerina Spicakova,
- Jone Ortiz de Zarate,
- Emilio Torrella Cortés,
- Ana Gutiérrez,
- Horacio Alonso-Galán,
- Álvaro Hernández-Martínez,
- José Miguel Marrero,
- Rufo Lorente Poyatos,
- Margalida Calafat,
- Lidia Martí Romero,
- Pilar Robledo,
- Orencio Bosch,
- Nuria Jiménez,
- María Esteve Comas,
- José María Duque,
- Ana María Fuentes Coronel,
- Manuela Josefa Sampedro,
- Eva Sesé Abizanda,
- Belén Herreros Martínez,
- Liliana Pozzati,
- Hipólito Fernández Rosáenz,
- Belén Crespo Suarez,
- Pilar López Serrano,
- Alfredo J. Lucendo,
- Margarita Muñoz Vicente,
- Fernando Bermejo,
- José Joaquín Ramírez Palanca,
- Margarita Menacho,
- Amalia Carmona,
- Raquel Camargo,
- Sandra Torra Alsina,
- Nuria Maroto,
- Juan Nerín de la Puerta,
- Elena Castro,
- Ignacio Marín-Jiménez,
- Belén Botella,
- Amparo Sapiña,
- Noelia Cruz,
- José Luis F. Forcelledo,
- Abdel Bouhmidi,
- Carlos Castaño-Milla,
- Verónica Opio,
- Isabel Nicolás,
- Marcos Kutz,
- Alfredo Abraldes Bechiarelli,
- Jordi Gordillo,
- Yolanda Ber,
- Yolanda Torres Domínguez,
- María Teresa Novella Durán,
- Silvia Rodríguez Mondéjar,
- Francisco J. Martínez-Cerezo,
- Lilyan Kolle,
- Miriam Sabat,
- Cesar Ledezma,
- Eduardo Iyo,
- Óscar Roncero,
- Rebeca Irisarri,
- Laia Lluis,
- Isabel Blázquez Gómez,
- Eva María Zapata,
- María José Alcalá,
- Cristina Martínez Pascual,
- María Montealegre,
- Laura Mata,
- Ana Monrobel,
- Alejandro Hernández Camba,
- Luis Hernández,
- María Tejada,
- Alberto Mir,
- María Luisa Galve,
- Marta Soler,
- Daniel Hervías,
- José Antonio Gómez-Valero,
- Manuel Barreiro-de Acosta,
- Fernando Rodríguez-Artalejo,
- Esther García-Esquinas,
- Javier P. Gisbert,
- on behalf of the EpidemIBD study group of GETECCU
Affiliations
- María Chaparro
- Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid, and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, Spain
- Ana Garre
- Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid, and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, Spain
- Andrea Núñez Ortiz
- Department of Gastroenterology, Hospital Universitario Virgen del Rocío, 41013 Sevilla, Spain
- María Teresa Diz-Lois Palomares
- Department of Gastroenterology, Hospital Universitario A Coruña, 15006 A Coruña, Spain
- Cristina Rodríguez
- Department of Gastroenterology, Complejo Hospitalario de Navarra, 31008 Pamplona, Spain
- Sabino Riestra
- Department of Gastroenterology, Hospital Universitario Central de Asturias and ISPA, 33011 Oviedo, Spain
- Milagros Vela
- Department of Gastroenterology, Complejo Hospitalario Universitario Ntra. Sra. de Candelaria, 38010 Santa Cruz de Tenerife, Spain
- José Manuel Benítez
- Department of Gastroenterology, Hospital Universitario Reina Sofía and IMIBIC, 14004 Córdoba, Spain
- Estela Fernández Salgado
- Department of Gastroenterology, Complexo Hospitalario Universitario de Pontevedra, Instituto de Investigación Sanitaria Galicia Sur, 36071 Pontevedra, Spain
- Eugenia Sánchez Rodríguez
- Department of Gastroenterology, Hospital Ramón y Cajal, 28034 Madrid, Spain
- Vicent Hernández
- Department of Gastroenterology, Hospital Álvaro Cunqueiro, Estrutura Organizativa de Xestión Integrada de Vigo, 36213 Vigo, Spain
- Rocío Ferreiro-Iglesias
- Department of Gastroenterology, Complexo Hospitalario Universitario de Santiago, 15706 Santiago de Compostela, Spain
- Ángel Ponferrada Díaz
- Department of Gastroenterology, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain
- Jesús Barrio
- Department of Gastroenterology, Hospital Universitario Rio Hortega, 47012 Valladolid, Spain
- José María Huguet
- Department of Gastroenterology, Consorcio Hospital General Universitario de Valencia, 46014 Valencia, Spain
- Beatriz Sicilia
- Department of Gastroenterology, Hospital Universitario de Burgos, 09006 Burgos, Spain
- María Dolores Martín-Arranz
- Department of Gastroenterology, Hospital Universitario La Paz, 28046 Madrid, Spain
- Xavier Calvet
- Servei de Malalties Digestives, Hospital de Sabadell, Institut Universitari Parc Taulí, Universitat Autònoma de Barcelona, CIBEREHD—Instituto de Salud Carlos III, Parc Taulí, 1, 08208 Sabadell, Barcelona, Spain
- Daniel Ginard
- Department of Gastroenterology, Hospital Universitari Son Espases, 07120 Palma de Mallorca, Spain
- Inmaculada Alonso-Abreu
- Department of Gastroenterology, Hospital Universitario de Canarias (H.U.C.), 38320 Santa Cruz de Tenerife, Spain
- Luis Fernández-Salazar
- Department of Gastroenterology, Hospital Clínico Universitario de Valladolid, 47003 Valladolid, Spain
- Pilar Varela Trastoy
- Department of Gastroenterology, Hospital de Cabueñes, 33394 Gijón, Spain
- Montserrat Rivero
- Department of Gastroenterology, Hospital Universitario Marqués de Valdecilla and IDIVAL, 39008 Santander, Spain
- Isabel Vera-Mendoza
- Department of Gastroenterology, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain
- Pablo Vega
- Department of Gastroenterology, Complexo Hospitalario Universitario de Ourense, 32005 Ourense, Spain
- Pablo Navarro
- Department of Gastroenterology, Hospital Clínico Universitario de Valencia, Universitat de València, 46010 Valencia, Spain
- Mónica Sierra
- Department of Gastroenterology, Complejo Asistencial Universitario de León, 24001 León, Spain
- José Luis Cabriada
- Department of Gastroenterology, Hospital de Galdakao-Usansolo, Galdakao, 48960 Vizcaya, Spain
- Mariam Aguas
- Department of Gastroenterology, Hospital Universitari i Politecnic La Fe and CIBERehd, 46026 Valencia, Spain
- Raquel Vicente
- Department of Gastroenterology, Hospital Universitario Miguel Servet, 50009 Zaragoza, Spain
- Mercè Navarro-Llavat
- Department of Gastroenterology, Hospital de Sant Joan Despí Moisès Broggi, 08970 Barcelona, Spain
- Ana Echarri
- Department of Gastroenterology, Complejo Hospitalario Universitario de Ferrol, 15405 A Coruña, Spain
- Fernando Gomollón
- Department of Gastroenterology, Hospital Clínico Universitario “Lozano Blesa”, IIS Aragón and CIBERehd, 50009 Zaragoza, Spain
- Elena Guerra del Río
- Department of Gastroenterology, Hospital Universitario de Gran Canaria Dr. Negrín, 35010 Las Palmas, Spain
- Concepción Piñero
- Department of Gastroenterology, Hospital Universitario de Salamanca, 37007 Salamanca, Spain
- María José Casanova
- Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid, and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, Spain
- Katerina Spicakova
- Department of Gastroenterology, Hospital Universitario de Araba (sede Txagorritxu y sede Santiago), 01009 Álava, Spain
- Jone Ortiz de Zarate
- Department of Gastroenterology, Hospital Universitario de Basurto, 48013 Bilbao, Spain
- Emilio Torrella Cortés
- Department of Gastroenterology, Hospital General Universitario J.M. Morales Meseguer, 30008 Murcia, Spain
- Ana Gutiérrez
- Department of Gastroenterology, Hospital General Universitario de Alicante and CIBERehd, 03010 Alicante, Spain
- Horacio Alonso-Galán
- Department of Gastroenterology, Hospital Universitario Donostia-Donostia Unibertsitate Ospitalea, Guipuzkoa and Organizacion Sanitaria Integrada Tolosaldea, Clínica Santa María de la Asunción, 20014 Guipúzcoa, Spain
- Álvaro Hernández-Martínez
- Department of Gastroenterology, Complejo Hospitalario de Especialidades Torrecárdenas, 04009 Almería, Spain
- José Miguel Marrero
- Department of Gastroenterology, Hospital Universitario Insular de Gran Canaria, 35016 Las Palmas, Spain
- Rufo Lorente Poyatos
- Department of Gastroenterology, Hospital General Universitario de Ciudad Real, 13005 Ciudad Real, Spain
- Margalida Calafat
- Department of Gastroenterology, Hospital Son Llatzer, 07198 Palma de Mallorca, Spain
- Lidia Martí Romero
- Department of Gastroenterology, Hospital Francesc De Borja de Gandía, 46702 Valencia, Spain
- Pilar Robledo
- Department of Gastroenterology, Hospital Universitario de Cáceres, 10004 Cáceres, Spain
- Orencio Bosch
- Department of Gastroenterology, Hospital Universitario Fundación Jiménez Díaz, 28040 Madrid, Spain
- Nuria Jiménez
- Department of Gastroenterology, Hospital General Universitario de Elche, 03203 Alicante, Spain
- María Esteve Comas
- Department of Gastroenterology, Hospital Universitari Mutua Terrasa, 08221 Terrassa, Spain
- José María Duque
- Department of Gastroenterology, Hospital San Agustín, 33401 Avilés, Spain
- Ana María Fuentes Coronel
- Department of Gastroenterology, Hospital Virgen de La Concha, Complejo Asistencial de Zamora, 49022 Zamora, Spain
- Manuela Josefa Sampedro
- Department of Gastroenterology, CSDM, Hospital de Mataró, 08304 Barcelona, Spain
- Eva Sesé Abizanda
- Department of Gastroenterology, Hospital Universitario Arnau de Vilanova, 25198 Lérida, Spain
- Belén Herreros Martínez
- Department of Gastroenterology, Hospital De Villajoyosa, 03570 Alicante, Spain
- Liliana Pozzati
- Department of Gastroenterology, Hospital de Mérida, 06800 Mérida, Spain
- Hipólito Fernández Rosáenz
- Department of Gastroenterology, Hospital San Pedro, 26006 Logroño, Spain
- Belén Crespo Suarez
- Department of Gastroenterology, Hospital da Costa (EOXI Lugo-Cervo-Monforte), 27880 Lugo, Spain
- Pilar López Serrano
- Department of Gastroenterology, Hospital Universitario Fundación Alcorcón, 28922 Madrid, Spain
- Alfredo J. Lucendo
- Department of Gastroenterology, Hospital General de Tomelloso, 13700 Tomelloso, Spain
- Margarita Muñoz Vicente
- Department of Gastroenterology, Hospital General Universitario de Castellón, 12004 Castellón, Spain
- Fernando Bermejo
- Department of Gastroenterology, Hospital Universitario de Fuenlabrada and Instituto de Investigación Sanitaria Hospital La Paz (IdiPaz), 28942 Madrid, Spain
- José Joaquín Ramírez Palanca
- Department of Gastroenterology, Hospital Lluis Alcanyis, Xátiva, 46800 Valencia, Spain
- Margarita Menacho
- Department of Gastroenterology, Hospital Joan XXIII, 43005 Tarragona, Spain
- Amalia Carmona
- Department of Gastroenterology, Hospital Povisa, 36211 Pontevedra, Spain
- Raquel Camargo
- Department of Gastroenterology, Complejo Hospitalario de Especialidades Virgen de la Victoria, 29010 Málaga, Spain
- Sandra Torra Alsina
- Department of Gastroenterology, Parc Sanitari Sant Joan de Déu, 08830 Barcelona, Spain
- Nuria Maroto
- Department of Gastroenterology, Hospital de Manises, 46940 Valencia, Spain
- Juan Nerín de la Puerta
- Department of Gastroenterology, Hospital Royo Villanova, 50015 Zaragoza, Spain
- Elena Castro
- Department of Gastroenterology, Complexo Hospitalario Universitario Xeral-Calde de Lugo, 27004 Lugo, Spain
- Ignacio Marín-Jiménez
- Department of Gastroenterology, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Biomédica Gregorio Marañón (IiSGM), 28007 Madrid, Spain
- Belén Botella
- Department of Gastroenterology, Hospital Universitario Infanta Cristina, 28981 Madrid, Spain
- Amparo Sapiña
- Department of Gastroenterology, Hospital de Manacor, 07500 Manacor, Spain
- Noelia Cruz
- Department of Gastroenterology, Hospital Doctor José Molina Orosa, 35500 Lanzarote, Spain
- José Luis F. Forcelledo
- Department of Gastroenterology, Hospital Comarcal Sierrallana, 39300 Torrelavega, Spain
- Abdel Bouhmidi
- Department of Gastroenterology, Hospital Santa Bárbara, 13500 Puertollano, Spain
- Carlos Castaño-Milla
- Department of Gastroenterology, Hospital Rey Juan Carlos, 28933 Madrid, Spain
- Verónica Opio
- Department of Gastroenterology, Hospital Universitario de Getafe, 28905 Madrid, Spain
- Isabel Nicolás
- Department of Gastroenterology, Hospital General Universitario Reina Sofía, 30003 Murcia, Spain
- Marcos Kutz
- Department of Gastroenterology, Hospital Reina Sofía, 31500 Tudela, Spain
- Alfredo Abraldes Bechiarelli
- Department of Gastroenterology, Hospital Puerta del Mar, 11009 Cádiz, Spain
- Jordi Gordillo
- Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain
- Yolanda Ber
- Department of Gastroenterology, Hospital San Jorge, 22004 Huesca, Spain
- Yolanda Torres Domínguez
- Department of Gastroenterology, Hospital San Juan de Dios del Aljarafe, 41930 Sevilla, Spain
- María Teresa Novella Durán
- Department of Gastroenterology, Hospital Can Misses, 07800 Ibiza, Spain
- Silvia Rodríguez Mondéjar
- Department of Gastroenterology, Hospital Sant Joan de Deu, 08950 Barcelona, Spain
- Francisco J. Martínez-Cerezo
- Department of Gastroenterology, Hospital Universitari Sant Joan, 25001 Lérida, Spain
- Lilyan Kolle
- Department of Gastroenterology, Hospital General de La Palma, 38713 Santa Cruz de Tenerife, Spain
- Miriam Sabat
- Department of Gastroenterology, Hospital Santa Caterina, 17190 Gerona, Spain
- Cesar Ledezma
- Department of Gastroenterology, Hospital Palamós, 17230 Girona, Spain
- Eduardo Iyo
- Department of Gastroenterology, Hospital Comarcal de Inca, 07300 Inca, Spain
- Óscar Roncero
- Department of Gastroenterology, Hospital General La Mancha Centro, 13600 Ciudad Real, Spain
- Rebeca Irisarri
- Department of Gastroenterology, Hospital García Orcoyen, 31200 Estella, Spain
- Laia Lluis
- Department of Gastroenterology, Hospital Sagrat Cor, 08029 Barcelona, Spain
- Isabel Blázquez Gómez
- Department of Gastroenterology, Hospital de Torrejón, 28850 Madrid, Spain
- Eva María Zapata
- Department of Gastroenterology, Hospital de Mendaro, 20850 Guipuzkoa, Spain
- María José Alcalá
- Department of Gastroenterology, Hospital Obispo Polanco, 44002 Teruel, Spain
- Cristina Martínez Pascual
- Department of Gastroenterology, Hospital General Universitario Los Arcos del Mar Menor, San Javier, 30739 Murcia, Spain
- María Montealegre
- Department of Gastroenterology, Hospital General de Villarobledo, 02600 Albacete, Spain
- Laura Mata
- Department of Gastroenterology, Hospital Medina del Campo, 47400 Valladolid, Spain
- Ana Monrobel
- Department of Gastroenterology, Hospital de Montilla, 14550 Córdoba, Spain
- Alejandro Hernández Camba
- Department of Gastroenterology, Hospital Quirón Costa Adeje, 38660 Santa Cruz de Tenerife, Spain
- Luis Hernández
- Department of Gastroenterology, Hospital Santos Reyes, 09400 Aranda de Duero, Spain
- María Tejada
- Department of Gastroenterology, Clínica Astarté, 11011 Cádiz, Spain
- Alberto Mir
- Department of Gastroenterology, Hospital Ernest Lluch, 50299 Zaragoza, Spain
- María Luisa Galve
- Department of Gastroenterology, Hospital Central de La Cruz Roja San José y Santa Adela, 28003 Madrid, Spain
- Marta Soler
- Department of Gastroenterology, Hospital San Juan De Dios, 38009 Tenerife, Spain
- Daniel Hervías
- Department of Gastroenterology, Hospital Virgen de Altagracia, 13002 Manzanares, Spain
- José Antonio Gómez-Valero
- Department of Gastroenterology, Hospital Dexeus, 08028 Barcelona, Spain
- Manuel Barreiro-de Acosta
- Department of Gastroenterology, Complexo Hospitalario Universitario de Santiago, 15706 Santiago de Compostela, Spain
- Fernando Rodríguez-Artalejo
- Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid/IdiPaz and CIBERESP, 28029 Madrid, Spain
- Esther García-Esquinas
- Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid/IdiPaz and CIBERESP, 28029 Madrid, Spain
- Javier P. Gisbert
- Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid, and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, Spain
- on behalf of the EpidemIBD study group of GETECCU
- DOI
- https://doi.org/10.3390/jcm10132885
- Journal volume & issue
-
Vol. 10,
no. 13
p. 2885
Abstract
(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD—Crohn’s disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)—during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100,000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31–56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery.
Keywords