A Non–Enzymatic Electrochemical Sensor of Cu@Co–MOF Composite for Glucose Detection with High Sensitivity and Selectivity
Zhen-Zhen Ma,
Yue-Shu Wang,
Bing Liu,
Huan Jiao,
Ling Xu
Affiliations
Zhen-Zhen Ma
Key Laboratory of Macromolecular Science of Shaanxi Province, Shaanxi Key Laboratory for Advanced Energy Devices, Shaanxi Engineering Laboratory for Advanced Energy Technology, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi’an 710062, China
Yue-Shu Wang
Key Laboratory of Macromolecular Science of Shaanxi Province, Shaanxi Key Laboratory for Advanced Energy Devices, Shaanxi Engineering Laboratory for Advanced Energy Technology, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi’an 710062, China
Bing Liu
Shaanxi Key Laboratory of Chemical Additives for Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi’an 710021, China
Huan Jiao
Key Laboratory of Macromolecular Science of Shaanxi Province, Shaanxi Key Laboratory for Advanced Energy Devices, Shaanxi Engineering Laboratory for Advanced Energy Technology, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi’an 710062, China
Ling Xu
Key Laboratory of Macromolecular Science of Shaanxi Province, Shaanxi Key Laboratory for Advanced Energy Devices, Shaanxi Engineering Laboratory for Advanced Energy Technology, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi’an 710062, China
A 3D cobalt metal–organic framework (Co–MOF), [Co3(BDC)3(DMU)2], was utilized to prepare Cu@Co–MOF composite in a deposition–reduction process. Cu@Co–MOF/GCE (GCE = glassy carbon electrode) electrode was prepared by “drop–coating” method. Cu@Co–MOF/GCE shows excellent electrocatalytic activity for Glu detection. The chronoamperometric response of Cu@Co–MOF/GCE to Glu concentration (CGlu) displays linear relationships in two CGlu sections with calculated sensitivities of 282.89 μA mM−1 cm−2 within 0.005–0.4 mM Glu and 113.15 μA mM−1 cm−2 within 0.4–1.8 mM Glu. The detection limit is calculated as 1.6 μM at S/N = 3. Cu@Co–MOF/GCE also exhibits a rapid current response, high anti–interference, stability, and repeatability to Glu detection. Cu@Co–MOF/GCE was applied to detect Glu in human serum and orange juice. All found CGlu are very close to those added CGlu with low RSDs and high recoveries. Cu@Co–MOF/GCE as a non–enzymatic electrochemical sensor of Glu has high sensitivity, selectivity, accuracy, and reliability.
