Substrate-induced conformational dynamics of the dopamine transporter

Anne Kathrine Nielsen; Ingvar R. Möller; Yong Wang; Søren G. F. Rasmussen; Kresten Lindorff-Larsen; Kasper D. Rand; Claus J. Loland

doi:10.1038/s41467-019-10449-w

Nature Communications (Jun 2019)

Substrate-induced conformational dynamics of the dopamine transporter

Anne Kathrine Nielsen,
Ingvar R. Möller,
Yong Wang,
Søren G. F. Rasmussen,
Kresten Lindorff-Larsen,
Kasper D. Rand,
Claus J. Loland

Affiliations

Anne Kathrine Nielsen: Laboratory for Membrane Protein Dynamics, Department of Neuroscience, University of Copenhagen
Ingvar R. Möller: Laboratory for Membrane Protein Dynamics, Department of Neuroscience, University of Copenhagen
Yong Wang: Structural Biology and NMR Laboratory, Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen
Søren G. F. Rasmussen: Department of Neuroscience, University of Copenhagen
Kresten Lindorff-Larsen: Structural Biology and NMR Laboratory, Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen
Kasper D. Rand: Protein Analysis Group, Department of Pharmacy, University of Copenhagen
Claus J. Loland: Laboratory for Membrane Protein Dynamics, Department of Neuroscience, University of Copenhagen

DOI: https://doi.org/10.1038/s41467-019-10449-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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The dopamine transporter is responsible for termination of neurotransmission through Na+-driven reuptake of neurotransmitter from the extracellular space. Here authors use hydrogen-deuterium exchange mass spectrometry to monitor Na+- and dopamine-induced conformational dynamics of the dopamine transporter.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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