O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity

Yunfan Yang; Minnie Fu; Min-Dian Li; Kaisi Zhang; Bichen Zhang; Simeng Wang; Yuyang Liu; Weiming Ni; Qunxiang Ong; Jia Mi; Xiaoyong Yang

doi:10.1038/s41467-019-13914-8

Nature Communications (Jan 2020)

O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity

Yunfan Yang,
Minnie Fu,
Min-Dian Li,
Kaisi Zhang,
Bichen Zhang,
Simeng Wang,
Yuyang Liu,
Weiming Ni,
Qunxiang Ong,
Jia Mi,
Xiaoyong Yang

Affiliations

Yunfan Yang: Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine
Minnie Fu: Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine
Min-Dian Li: Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine
Kaisi Zhang: Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine
Bichen Zhang: Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine
Simeng Wang: Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine
Yuyang Liu: Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine
Weiming Ni: Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine
Qunxiang Ong: Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine
Jia Mi: Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine
Xiaoyong Yang: Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine

DOI: https://doi.org/10.1038/s41467-019-13914-8
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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Post-translational O-linked β-N acetylglucosamine (O-GlcNAc) modification acts as a nutrient-sensing mechanism. Here the authors report that O-GlcNAc transferase inhibits adipose tissue lipolysis via O-GlcNAcylation of the lipid droplet protein perilipin 1 and thus promotes diet-induced obesity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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