Frontiers in Pharmacology (May 2022)
Huangqi Guizhi Wuwu Decoction Improves Arthritis and Pathological Damage of Heart and Lung in TNF-Tg Mice
- Yi Wang,
- Yi Wang,
- Yi Wang,
- Tao Chen,
- Tao Chen,
- Tao Chen,
- Tao Chen,
- Can Yang,
- Can Yang,
- Can Yang,
- Qiang Li,
- Qiang Li,
- Qiang Li,
- Mengjiao Ma,
- Mengjiao Ma,
- Mengjiao Ma,
- Hao Xu,
- Hao Xu,
- Hao Xu,
- Qi Shi,
- Qi Shi,
- Qi Shi,
- Yongjun Wang,
- Yongjun Wang,
- Yongjun Wang,
- Youhua Wang,
- Youhua Wang,
- Youhua Wang,
- Qianqian Liang,
- Qianqian Liang,
- Qianqian Liang
Affiliations
- Yi Wang
- Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Yi Wang
- Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Yi Wang
- Cardiovascular Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Tao Chen
- Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Tao Chen
- Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Tao Chen
- Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Tao Chen
- Central Hospital of Jing’an District, Fudan University, Shanghai, China
- Can Yang
- Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Can Yang
- Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Can Yang
- Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Qiang Li
- Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Qiang Li
- Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Qiang Li
- Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Mengjiao Ma
- Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Mengjiao Ma
- Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Mengjiao Ma
- Cardiovascular Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Hao Xu
- Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Hao Xu
- Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Hao Xu
- Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Qi Shi
- Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Qi Shi
- Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Qi Shi
- Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Yongjun Wang
- Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Yongjun Wang
- Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Yongjun Wang
- Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Youhua Wang
- Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Youhua Wang
- Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Youhua Wang
- Cardiovascular Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Qianqian Liang
- Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Qianqian Liang
- Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Qianqian Liang
- Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- DOI
- https://doi.org/10.3389/fphar.2022.871481
- Journal volume & issue
-
Vol. 13
Abstract
Background: Huangqi Guizhi Wuwu Decoction (HGWD) is a traditional and effective Chinese medicine compound decoction for the treatment of rheumatoid arthritis (RA). However, there is few research on the treatment of rheumatoid cardiopulmonary complications. The present study was to study whether HGWD can alleviate the pathological changes caused by rheumatoid arthritis and cardiopulmonary complications.Methods: Five 3-month-old TNF-Tg mice were treated with HGWD (9.1 g/kg) once a day or the same dose of normal saline lasted for 8 weeks, and wild-type littermates of the same age were used as a negative control, and methotrexate (MTX) was intraperitoneally administered as a positive control. After the treatment, pathological staining was performed on the mouse ankle joints, heart, and lungs.Result: It was found that HGWD reduced the inflammation of the ankle joint synovium in TNF-Tg mice, and reduced myocardial hypertrophy, inflammatory infiltration and fibrosis of heart, as well as lung inflammation and fibrosis. Immunohistochemical staining with anti-TNF-α antibody showed that HGWD reduced the expression of TNF-α in the heart of TNF-Tg mice.Conclusion: In conclusion, HGWD alleviates joint inflammation in TNF-Tg mice and reduces the pathological changes of the heart and lungs.
Keywords
- Huangqi Guizhi Wuwu Decoction
- rheumatoid arthritis
- cardiopulmonary complications of RA
- TNF-Tg mice
- traditional Chinese medicine