A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response

Charles S. Fermaintt; Kanae Sano; Zhida Liu; Nozomi Ishii; Junichi Seino; Nicole Dobbs; Tadashi Suzuki; Yang-Xin Fu; Mark A. Lehrman; Ichiro Matsuo; Nan Yan

doi:10.1038/s41467-019-10319-5

Nature Communications (May 2019)

A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response

Charles S. Fermaintt,
Kanae Sano,
Zhida Liu,
Nozomi Ishii,
Junichi Seino,
Nicole Dobbs,
Tadashi Suzuki,
Yang-Xin Fu,
Mark A. Lehrman,
Ichiro Matsuo,
Nan Yan

Affiliations

Charles S. Fermaintt: Department of Immunology, University of Texas Southwestern Medical Center
Kanae Sano: Division of Molecular Science, Gunma University
Zhida Liu: Department of Pathology, University of Texas Southwestern Medical Center
Nozomi Ishii: Division of Molecular Science, Gunma University
Junichi Seino: Glycometabolic Biochemistry Laboratory, RIKEN Cluster for Pioneering Research
Nicole Dobbs: Department of Immunology, University of Texas Southwestern Medical Center
Tadashi Suzuki: Glycometabolic Biochemistry Laboratory, RIKEN Cluster for Pioneering Research
Yang-Xin Fu: Department of Pathology, University of Texas Southwestern Medical Center
Mark A. Lehrman: Department of Pharmacology, Department of Microbiology, University of Texas Southwestern Medical Center
Ichiro Matsuo: Division of Molecular Science, Gunma University
Nan Yan: Department of Immunology, University of Texas Southwestern Medical Center

DOI: https://doi.org/10.1038/s41467-019-10319-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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Mammalian glycans have a role in host immunity but little is known about how they activate the host response in the context of autoimmune diseases. Here, the authors identify Manβ1-4GlcNAc as a novel innate immune modulator associated with chronic autoimmune diseases.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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