Acetate attenuates hyperoxaluria-induced kidney injury by inhibiting macrophage infiltration via the miR-493-3p/MIF axis

Wei Zhu; Chengjie Wu; Zhen Zhou; Guangyuan Zhang; Lianmin Luo; Yang Liu; Zhicong Huang; Guoyao Ai; Zhijian Zhao; Wen Zhong; Yongda Liu; Guohua Zeng

doi:10.1038/s42003-023-04649-w

Communications Biology (Mar 2023)

Acetate attenuates hyperoxaluria-induced kidney injury by inhibiting macrophage infiltration via the miR-493-3p/MIF axis

Wei Zhu,
Chengjie Wu,
Zhen Zhou,
Guangyuan Zhang,
Lianmin Luo,
Yang Liu,
Zhicong Huang,
Guoyao Ai,
Zhijian Zhao,
Wen Zhong,
Yongda Liu,
Guohua Zeng

Affiliations

Wei Zhu: Department of Urology and Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University
Chengjie Wu: Department of Urology and Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University
Zhen Zhou: Department of Urology and Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University
Guangyuan Zhang: Department of Urology, Zhongda Hospital Southeast University
Lianmin Luo: Department of Urology and Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University
Yang Liu: Department of Urology and Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University
Zhicong Huang: Department of Urology and Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University
Guoyao Ai: Department of Urology and Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University
Zhijian Zhao: Department of Urology and Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University
Wen Zhong: Department of Urology and Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University
Yongda Liu: Department of Urology and Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University
Guohua Zeng: Department of Urology and Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University

DOI: https://doi.org/10.1038/s42003-023-04649-w
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 12

Abstract

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Acetate promotes miR-493-3p expression, which in turn suppresses the expression of macrophage migration inhibitory factor, leading to decreased macrophages recruitment and reduced hyperoxaluria-induced renal injury in mice.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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