Susceptibility to SARS-CoV-2 and MERS-CoV in Beagle Dogs
Kwang-Soo Lyoo,
Yoon-Hwan Yeo,
Sung-Geun Lee,
Minjoo Yeom,
Joo-Yeon Lee,
Kyung-Chang Kim,
Daesub Song
Affiliations
Kwang-Soo Lyoo
Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of Korea
Yoon-Hwan Yeo
Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of Korea
Sung-Geun Lee
Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of Korea
Minjoo Yeom
Department of Veterinary Medicine Virology Laboratory, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of Korea
Joo-Yeon Lee
Division of Emerging Infectious Disease and Vector Research, Center for Infectious Diseases Research, National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju 28159, Republic of Korea
Kyung-Chang Kim
Division of Emerging Infectious Disease and Vector Research, Center for Infectious Diseases Research, National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju 28159, Republic of Korea
Daesub Song
Department of Veterinary Medicine Virology Laboratory, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of Korea
The coronavirus disease 19 (COVID-19) pandemic, caused by the severe acute respiratory syndrome, coronavirus 2 (SARS-CoV-2), has resulted in unprecedented challenges to healthcare worldwide. In particular, the anthroponotic transmission of human coronaviruses has become a common concern among pet owners. Here, we experimentally inoculated beagle dogs with SARS-CoV-2 or Middle East respiratory syndrome (MERS-CoV) to compare their susceptibility to and the pathogenicity of these viruses. The dogs in this study exhibited weight loss and increased body temperatures and shed the viruses in their nasal secretions, feces, and urine. Pathologic changes were observed in the lungs of the dogs inoculated with SARS-CoV-2 or MERS-CoV. Additionally, clinical characteristics of SARS-CoV-2, such as increased lactate dehydrogenase levels, were identified in the current study.
