Milestones in the history of thalassemia and sickle cell disease

Abstract

The inherited hemoglobin disorders are a challenging topic for many reasons; they are caused by a variety of interesting molecular mechanisms, have a complicated pathophysiology, they constitute a multifaceted medical problem with pain and misery for the patients and unhappiness for their families, create several diagnostic and therapeutic questions, and they have a huge social and economic impact across the countries where they occur in high frequencies.