Cancer Management and Research (Dec 2022)

Capecitabine and Temozolomide (CAPTEM) in Advanced Neuroendocrine Neoplasms (NENs): A Systematic Review and Pooled Analysis

  • Arrivi G,
  • Verrico M,
  • Roberto M,
  • Barchiesi G,
  • Faggiano A,
  • Marchetti P,
  • Mazzuca F,
  • Tomao S

Journal volume & issue
Vol. Volume 14
pp. 3507 – 3523

Abstract

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Giulia Arrivi,1 Monica Verrico,2,3 Michela Roberto,2 Giacomo Barchiesi,2 Antongiulio Faggiano,4 Paolo Marchetti,1,5 Federica Mazzuca,1,* Silverio Tomao2,* 1Department of Clinical and Molecular Medicine, Oncology Unit, Sant’ Andrea University Hospital, Sapienza University of Rome, Rome, Italy; 2Department of Radiological, Oncological and Anatomo-Pathological Sciences, Medical Oncology Unit A, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy; 3Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy; 4Department of Clinical and Molecular Medicine, Endocrinology Unit, Sant ‘Andrea University Hospital, Sapienza University of Rome, Rome, Italy; 5Istituto Dermopatico dell’Immacolata (IDI-IRCCS), Rome, Italy*These authors contributed equally to this workCorrespondence: Michela Roberto, Department of Radiological, Oncological and Anatomo-Pathological Sciences, Medical Oncology Unit A, Policlinico Umberto I, “Sapienza” University of Rome, Rome, Italy, Viale Regina Elena 324, Email [email protected]: Retrospective studies and single center experiences suggest a role of capecitabine combined with temozolomide (CAPTEM) in neuroendocrine tumors (NENs).Methods: We performed a systematic review to assess the efficacy and safety of CAPTEM in patients affected with NENs, with the aim to better clarify the role of this regimen in the therapeutic algorithm of NENs.Results: A total of 42 articles and 1818 patients were included in our review. The overall disease control rate was 77% (range 43.5%-100%). The median progression free survival ranged from 4 to 38.5 months, while the median overall survival ranged from 8 to 103 months. Safety analysis showed an occurrence of G3-G4 toxicities in 16.4% of the entire population. The most common toxicities were hematological (27.2%), gastrointestinal (8.3%,) and cutaneous (3.2%).Conclusion: This systematic review demonstrated that CAPTEM was an effective and relatively safe treatment for patients with advanced well-moderate differentiated NENs of gastroenteropancreatic, lung and unknown origin.Graphical Abstract: Keywords: NENs, neuroendocrine, temozolomide, capecitabine, CAPTEM, chemotherapy

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