Development of polymeric composite scaffolds for defective bone repair and regeneration

Abstract

Abstract Bones are vital components of the body that provide soft internal organs and tissues with structure, motion, and safety. Damage to bones can make life challenging. In repairing and regenerating damaged bone, polymeric composite materials significantly contribute to bone tissue engineering. In this article, we described developing porous scaffolds using the freeze-drying process from sodium alginate (SA), polyvinyl alcohol (PVA), and graphene oxide (GO) incorporated with zinc (Zn). These scaffolds were characterized by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), and universal testing machine (UTM) to investigate their structural analysis, surface morphology, and mechanical behavior, respectively. These scaffolds also exhibited less swelling in phosphate buffer saline (34.73–64.27%) than in aqueous media (42.36–75.92%) with controlled degradation. These scaffolds have potential biomineralization activities, hemocompatibility, and antibacterial activities, which were increased by increasing the Zn amount. All the scaffolds have biocompatibility as they have shown cell viability with mature cell morphology against preosteoblast and HEK-293 cell lines under standard in vitro conditions. The enhanced biological activities of the scaffolds were found by increasing the Zn amount. Thus, newly designed polymeric composite scaffolds would be promising materials to repair and regenerate fractured bone tissue.

Keywords

• Antibacterial
• Biomineralization
• Composite materials
• Fractured bone
• Porous scaffolds
• Polymeric composite