Shedding of N-acetylglucosaminyltransferase-V is regulated by maturity of cellular N-glycan

Tetsuya Hirata; Misaki Takata; Yuko Tokoro; Miyako Nakano; Yasuhiko Kizuka

doi:10.1038/s42003-022-03697-y

Communications Biology (Aug 2022)

Shedding of N-acetylglucosaminyltransferase-V is regulated by maturity of cellular N-glycan

Tetsuya Hirata,
Misaki Takata,
Yuko Tokoro,
Miyako Nakano,
Yasuhiko Kizuka

Affiliations

Tetsuya Hirata: Institute for Glyco-core Research (iGCORE), Gifu University
Misaki Takata: Graduate School of Integrated Sciences for Life, Hiroshima University
Yuko Tokoro: Institute for Glyco-core Research (iGCORE), Gifu University
Miyako Nakano: Graduate School of Integrated Sciences for Life, Hiroshima University
Yasuhiko Kizuka: Institute for Glyco-core Research (iGCORE), Gifu University

DOI: https://doi.org/10.1038/s42003-022-03697-y
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

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Cleavage of the glycan-branching enzyme N-acetylglucosaminyltransferase-V (GnT-V) by signal peptide peptidase-like 3 (SPPL3) protease and extracellular secretion of active glycan GnT-V depend on GnT-V’s own glycosylation state.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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