Nature Communications (Sep 2019)
Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids
- Junki Miyamoto,
- Miki Igarashi,
- Keita Watanabe,
- Shin-ichiro Karaki,
- Hiromi Mukouyama,
- Shigenobu Kishino,
- Xuan Li,
- Atsuhiko Ichimura,
- Junichiro Irie,
- Yukihiko Sugimoto,
- Tetsuya Mizutani,
- Tatsuya Sugawara,
- Takashi Miki,
- Jun Ogawa,
- Daniel J. Drucker,
- Makoto Arita,
- Hiroshi Itoh,
- Ikuo Kimura
Affiliations
- Junki Miyamoto
- Department of Applied Biological Science, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
- Miki Igarashi
- Department of Applied Biological Science, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
- Keita Watanabe
- Department of Applied Biological Science, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
- Shin-ichiro Karaki
- Laboratory of Physiology, Department of Environmental and Life Sciences, University of Shizuoka
- Hiromi Mukouyama
- Department of Applied Biological Science, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
- Shigenobu Kishino
- Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake-cho
- Xuan Li
- Department of Applied Biological Science, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
- Atsuhiko Ichimura
- Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University
- Junichiro Irie
- AMED-CREST, Japan Agency for Medical Research and Development
- Yukihiko Sugimoto
- AMED-CREST, Japan Agency for Medical Research and Development
- Tetsuya Mizutani
- Research and Education Center for Prevention of Global Infectious Diseases of Animals, Faculty of Agriculture, Tokyo University of Agriculture and Technology
- Tatsuya Sugawara
- Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University
- Takashi Miki
- Department of Medical Physiology, Graduate School of Medicine, Chiba University
- Jun Ogawa
- Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake-cho
- Daniel J. Drucker
- Department of Medicine, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto
- Makoto Arita
- Division of Physiological Chemistry and Metabolism, Faculty of Pharmacy, Keio University
- Hiroshi Itoh
- AMED-CREST, Japan Agency for Medical Research and Development
- Ikuo Kimura
- Department of Applied Biological Science, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
- DOI
- https://doi.org/10.1038/s41467-019-11978-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
The gut microbiome is an important regulator of metabolic health. Here the authors show that intestinal bacteria metabolize dietary linoleic acid to 10-hydroxy-cis-12-octadecenoic acid (HYA) which confers host resistance to high fat diet-induced obesity in mice.
