Endocrine therapy for metastatic solid pseudopapillary neoplasm of the pancreas: A case report

Anna Kornietskaya; Sevindzh Evdokimova; Andrei Kachmazov; Alexander. Fedenko; Larisa Bolotina; Dmitriy Sidorov; Nadezhda Volchenko; Natalia Goeva; Anastasia Govaleshko; Andrey Kaprin; Andrey Kaprin

doi:10.3389/fonc.2022.970142

Frontiers in Oncology (Sep 2022)

Endocrine therapy for metastatic solid pseudopapillary neoplasm of the pancreas: A case report

Anna Kornietskaya,
Sevindzh Evdokimova,
Andrei Kachmazov,
Alexander. Fedenko,
Larisa Bolotina,
Dmitriy Sidorov,
Nadezhda Volchenko,
Natalia Goeva,
Anastasia Govaleshko,
Andrey Kaprin,
Andrey Kaprin

Affiliations

Anna Kornietskaya: P. Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Moscow, Russia
Sevindzh Evdokimova: P. Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Moscow, Russia
Andrei Kachmazov: P. Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Moscow, Russia
Alexander. Fedenko: P. Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Moscow, Russia
Larisa Bolotina: P. Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Moscow, Russia
Dmitriy Sidorov: City Clinical Oncological Hospital No1, Moscow, Russia
Nadezhda Volchenko: P. Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Moscow, Russia
Natalia Goeva: P. Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Moscow, Russia
Anastasia Govaleshko: P. Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Moscow, Russia
Andrey Kaprin: P. Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Moscow, Russia
Andrey Kaprin: Peoples’ Friendship University of Russia, Moscow, Russia

DOI: https://doi.org/10.3389/fonc.2022.970142
Journal volume & issue: Vol. 12

Abstract

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Solid pseudopapillary neoplasm (SPN) of the pancreas is an extremely rare tumor, associated with favorable prognosis and long-term survival in patients with advanced disease. However, limited data exist on systemic therapy for such patients. Herein, we present a case of a young woman with a history of SPN, who progressed after multiple surgical resections and chemotherapy regimens. The immunohistochemistry (IHC) showed overexpression of estrogen receptors (ER) and progesterone receptors (PR) in tumor tissue. The patient started to receive tamoxifen and showed a durable response to endocrine therapy.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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Abstract

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