Ex vivo-expanded human CD19+TIM-1+ regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis

Abstract

Human regulatory B (Breg) cells have been difficult to study due to their scarcity and heterogeneity. Here the authors expand human B cells to exert immunosuppressive function in vitro and in vivo, and to implicate the TIM-1/STAT3 axis for the regulation of their homoeostasis and function.