Role of PAD enzymes on histone citrullination in cancer

Abstract

Citrullination process is a natural pathway which happened at the time of cell dying, but during removal of these products, PAD enzymes may release causing stimuli to the immune system. This can start a consequence of processes and enhancement of cancer disease. In this review, we will focus on this marker and significance of its application for early detection of cancer and for follow-up disease, and the latest approved medications act on this line.

Keywords

• citrullination
• histone
• pad-4