Recent Advances in the Therapeutic Effects and Molecular Mechanisms of Baicalin
Xiaoyuan Qiu,
Renyin Huang,
Junke Xie,
Shanshan Luo,
Xiang Cheng,
Jing Cui,
Desheng Hu
Affiliations
Xiaoyuan Qiu
Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Renyin Huang
Jingshan Union Hospital, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, China
Junke Xie
Jingshan Union Hospital, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, China
Shanshan Luo
Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Xiang Cheng
Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Jing Cui
Health Management Center, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan 430015, China
Desheng Hu
Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Baicalin, a kind of polyphenolic flavonoid, is a major bioactive flavone derived from the root of Scutellaria baicalensis, which has been widely utilized in clinical practice in China for thousands of years. In recent years, it has attracted increasing attention due to its potential therapeutic properties observed in preclinical studies involving various disease models. However, the precise mechanisms underlying its biological activities have not been fully elucidated. This review summarizes recent research progress on the molecular mechanisms through which baicalin exerts its effects, particularly in tumor suppression, cardiovascular protection, neuronal preservation, and glucose and lipid metabolism regulation in murine models. Additionally, we discuss the delivery methods of baicalin and its transformation by intestinal microbiota.
