Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease

Shixian Hu; Werna T. Uniken Venema; Harm-Jan Westra; Arnau Vich Vila; Ruggero Barbieri; Michiel D. Voskuil; Tjasso Blokzijl; Bernadien H. Jansen; Yanni Li; Mark J. Daly; Ramnik J. Xavier; Gerard Dijkstra; Eleonora A. Festen; Rinse K. Weersma

doi:10.1038/s41467-021-21458-z

Nature Communications (Feb 2021)

Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease

Shixian Hu,
Werna T. Uniken Venema,
Harm-Jan Westra,
Arnau Vich Vila,
Ruggero Barbieri,
Michiel D. Voskuil,
Tjasso Blokzijl,
Bernadien H. Jansen,
Yanni Li,
Mark J. Daly,
Ramnik J. Xavier,
Gerard Dijkstra,
Eleonora A. Festen,
Rinse K. Weersma

Affiliations

Shixian Hu: Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen
Werna T. Uniken Venema: Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen
Harm-Jan Westra: Department of Genetics, University of Groningen and University Medical Center Groningen
Arnau Vich Vila: Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen
Ruggero Barbieri: Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen
Michiel D. Voskuil: Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen
Tjasso Blokzijl: Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen
Bernadien H. Jansen: Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen
Yanni Li: Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen
Mark J. Daly: Broad Institute of Harvard and Massachusetts Institute of Technology
Ramnik J. Xavier: Broad Institute of Harvard and Massachusetts Institute of Technology
Gerard Dijkstra: Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen
Eleonora A. Festen: Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen
Rinse K. Weersma: Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen

DOI: https://doi.org/10.1038/s41467-021-21458-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 10

Abstract

Read online

Inflammatory bowel diseases are heterogeneous, and little is known about how underlying genetic variation can affect their development. Here, the authors report that intestinal inflammation modulates the effect of host genetics on the gut mucosal expression of 190 genes in the context of inflammatory bowel diseases.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal