Nature Communications (May 2022)
Cortical Cyclin A controls spindle orientation during asymmetric cell divisions in Drosophila
Abstract
The Frizzled/Dishevelled planar cell polarity pathway is involved in mitotic spindle orientation, but how this is coordinated with the cell cycle is unclear. Here, the authors show with Drosophila sensory organ precursor cells that Cyclin A is recruited in prophase by Frizzled/Dishevelled, regulating division orientation.