DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol

Elizaveta O. Boldinova; Paulina H. Wanrooij; Evgeniy S. Shilkin; Sjoerd Wanrooij; Alena V. Makarova

doi:10.3390/ijms18071584

International Journal of Molecular Sciences (Jul 2017)

DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol

Elizaveta O. Boldinova,
Paulina H. Wanrooij,
Evgeniy S. Shilkin,
Sjoerd Wanrooij,
Alena V. Makarova

Affiliations

Elizaveta O. Boldinova: Institute of Molecular Genetics of Russian Academy of Sciences, Kurchatov sq. 2, 123182 Moscow, Russia
Paulina H. Wanrooij: Department of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden
Evgeniy S. Shilkin: Institute of Molecular Genetics of Russian Academy of Sciences, Kurchatov sq. 2, 123182 Moscow, Russia
Sjoerd Wanrooij: Department of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden
Alena V. Makarova: Institute of Molecular Genetics of Russian Academy of Sciences, Kurchatov sq. 2, 123182 Moscow, Russia

DOI: https://doi.org/10.3390/ijms18071584
Journal volume & issue: Vol. 18, no. 7
p. 1584

Abstract

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PrimPol is a human deoxyribonucleic acid (DNA) polymerase that also possesses primase activity and is involved in DNA damage tolerance, the prevention of genome instability and mitochondrial DNA maintenance. In this review, we focus on recent advances in biochemical and crystallographic studies of PrimPol, as well as in identification of new protein-protein interaction partners. Furthermore, we discuss the possible functions of PrimPol in both the nucleus and the mitochondria.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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